| Type: | Family | Name: | Dedicator of cytokinesis 6 |
| Description: | DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3,4), DOCK-C subfamily (DOCK 6, 7, 8), DOCK-D subfamily (DOCK 9, 10, 11) []. This entry represents DOCK6, which acts as guanine nucleotide exchange factor for Cdc42 and Rac1 small GTPases. Through activation of CDC42 and RAC1,it may regulate neurite outgrowth []. | Short Name: | DOCK6 |
