Protein Domain : IPR001949

Type:  Conserved_site Name:  NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Description:  NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51 kDa (in mammals), which is the second largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to NAD, FMN, and a 2Fe-2S cluster. The 51 kDa subunit and the bacterial hydrogenase alpha subunit contain three regions of sequence similarities. The first one most probably corresponds to the NAD-binding site, the second to the FMN-binding site, and the third one, which contains three cysteines, to the iron-sulphur binding region. Short Name:  NADH-UbQ_OxRdtase_51kDa_CS
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PS00644
PS00645

3 Found Ins

DB identifier Type Name
IPR019575 Domain NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain
IPR011538 Domain NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain
IPR011537 Family NADH ubiquinone oxidoreductase, F subunit

4 GO Annotations

GO Term Gene Name
GO:0008137 IPR001949
GO:0010181 IPR001949
GO:0051539 IPR001949
GO:0055114 IPR001949

4 Ontology Annotations

GO Term Gene Name
GO:0008137 IPR001949
GO:0010181 IPR001949
GO:0051539 IPR001949
GO:0055114 IPR001949

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1470679
            10940377
            18394423