| Type: | Conserved_site | Name: | Solute-binding protein family 3, conserved site |
| Description: | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [, ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a conserved site found in the extracellular solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea.Familiy 3 members include:Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae. Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP. Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum. Arginine-binding proteins artI and artJ of Escherichia coli. Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens. Octopine-binding protein (gene occT) from Agrobacterium tumefaciens. Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni. Bacteroides nodosus protein aabA. Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis. Escherichia coli protein fliY. Vibrio harveyi protein patH. Escherichia coli hypothetical protein ydhW. Bacillus subtilis hypothetical protein yckB. Bacillus subtilis hypothetical protein yckK. | Short Name: | SBP_3_CS |
