GO Term : GO:0000837 Doa10p ubiquitin ligase complex GO

Namespace:  cellular_component Obsolete:  false
description  A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

32 Parents

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GO:0044446 intracellular organelle part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0098588 bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle.
GO:0044425 membrane part Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO:0012505 endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GO:0031090 organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
GO:0000153 cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm.
GO:0044432 endoplasmic reticulum part Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
GO:0000835 ER ubiquitin ligase complex A ubiquitin ligase complex found in the ER.

39 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0000835 GO:0000837
is_a GO:0000153 GO:0000837
is_a GO:0000151 GO:0000837
part of GO:0031090 GO:0000837
part of GO:0044424 GO:0000837
part of GO:0044446 GO:0000837
is_a GO:0098796 GO:0000837
part of GO:0044425 GO:0000837
is_a GO:0044432 GO:0000837
part of GO:0005737 GO:0000837
part of GO:0098588 GO:0000837
part of GO:0005575 GO:0000837
part of GO:0044464 GO:0000837
is_a GO:0032991 GO:0000837
part of GO:0043231 GO:0000837
part of GO:0044444 GO:0000837
part of GO:0044422 GO:0000837
part of GO:0043229 GO:0000837
is_a GO:1990234 GO:0000837
part of GO:0043227 GO:0000837
part of GO:0043226 GO:0000837
is_a GO:0000502 GO:0000837
part of GO:0016020 GO:0000837
is_a GO:0044464 GO:0000837
is_a GO:0005575 GO:0000837
is_a GO:0044444 GO:0000837
is_a GO:0043234 GO:0000837
is_a GO:0044422 GO:0000837
is_a GO:0044425 GO:0000837
is_a GO:0044424 GO:0000837

1 Synonyms

Name Type
Ssm4p ubiquitin ligase complex synonym