GO Term : GO:0043105 negative regulation of GTP cyclohydrolase I activity GO
Namespace:  biological_process Obsolete:  false
description  Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

23 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
GO:0003934 GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009892 negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044092 negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0051336 regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0019238 cyclohydrolase activity Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring.
GO:0003933 GTP cyclohydrolase activity Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.
GO:0051346 negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
GO:0043095 regulation of GTP cyclohydrolase I activity Any process that modulates the activity of the enzyme GTP cyclohydrolase I.
GO:0043105 negative regulation of GTP cyclohydrolase I activity Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I.

35 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0065007 GO:0043105
negatively regulates GO:0003934 GO:0043105
negatively regulates GO:0003934 GO:0043105
is_a GO:0043095 GO:0043105
is_a GO:0051346 GO:0043105
is_a GO:0050790 GO:0043105
negatively regulates GO:0003674 GO:0043105
regulates GO:0003824 GO:0043105
is_a GO:0044092 GO:0043105
negatively regulates GO:0003933 GO:0043105
regulates GO:0019238 GO:0043105
regulates GO:0008152 GO:0043105
is_a GO:0048519 GO:0043105
regulates GO:0016787 GO:0043105
is_a GO:0008150 GO:0043105
negatively regulates GO:0016810 GO:0043105
regulates GO:0008150 GO:0043105
is_a GO:0050789 GO:0043105
is_a GO:0043086 GO:0043105
negatively regulates GO:0016814 GO:0043105
regulates GO:0003934 GO:0043105
is_a GO:0051336 GO:0043105
regulates GO:0003933 GO:0043105
negatively regulates GO:0003824 GO:0043105
is_a GO:0019222 GO:0043105
negatively regulates GO:0016787 GO:0043105
is_a GO:0065007 GO:0043105
regulates GO:0016810 GO:0043105
negatively regulates GO:0008150 GO:0043105
negatively regulates GO:0019238 GO:0043105

4 Synonyms

Name Type
down regulation of GTP cyclohydrolase I activity synonym
downregulation of GTP cyclohydrolase I activity synonym
down-regulation of GTP cyclohydrolase I activity synonym
inhibition of GTP cyclohydrolase I activity synonym