| Type: | Family | Name: | Kae1/TsaD family |
| Description: | Members of this family have been linked to DNA maintenance in bacteria and mitochondria [] and transcription regulation and telomere homeostasis in eukaryotes [, ], but their function remained uncharacterised. A bacterial member of this family, Gcp, was originally thought to have endopeptidase activity [] but this could not be confirmed in other orthologues [, ]. Recent research indicates that this family is involved in the biosynthesis of N6-threonylcarbamoyl adenosine, a universal modification found at position 37 of tRNAs that read codons beginning with adenine []. | Short Name: | KAE1/TsaD |
