Protein Domain : IPR002220

Type:  Family Name:  DapA-like
Description:  Dihydrodipicolinate synthase (EC 4.2.1.52) (DHDPS) catalyses, in higher plants, some fungi and bacteria (gene dapA), the first reaction specific to the biosynthesis of lysine and of diaminopimelate []. DHDPS is responsible for the condensation of aspartate semialdehyde and pyruvate by a ping-pong mechanism in which pyruvate first binds to the enzyme by forming aSchiff-base with a lysine residue [, ].Other proteins are structurally related to DHDPS and probably also act via a similar catalytic mechanism []:Escherichia coli N-acetylneuraminate lyase (EC 4.1.3.3) (gene nanA), which catalyses the condensation of N-acetyl-D-mannosamine and pyruvate to formN-acetylneuraminate.Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase.D-4-deoxy-5-oxoglucarate dehydratase.Rhizobium meliloti protein mosA [], which is involved in the biosynthesis of the rhizopine 3-o-methyl-scyllo-inosamine.Thermoproteus tenax 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase (KdgA) []. Short Name:  DapA-like
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3 Child Features

DB identifier Type Name
IPR005263 Family 4-hydroxy-tetrahydrodipicolinate synthase, DapA
IPR017655 Family 5-dehydro-4-deoxyglucarate dehydratase
IPR005264 Family N-acetylneuraminate lyase

2 Contains

DB identifier Type Name
IPR020624 Conserved_site Schiff base-forming aldolase, conserved site
IPR020625 Active_site Schiff base-forming aldolase, active site

4 Cross Referencess

Identifier
PTHR12128
PF00701
PIRSF001365
PR00146

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0016829 IPR002220
GO:0008152 IPR002220

2 Ontology Annotations

GO Term Gene Name
GO:0016829 IPR002220
GO:0008152 IPR002220

0 Parent Features

834 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
179125 D8SEQ0 PAC:15407552 Selaginella moellendorffii 368  
evm.model.supercontig_18.130 PAC:16411272 Carica papaya 365  
29830.m001442 B9S6U4 PAC:16810184 Ricinus communis 367  
33535.m000028 B9TF72 PAC:16825890 Ricinus communis 297  
Cucsa.257740.2 PAC:16972751 Cucumis sativus 311  
Cucsa.257740.1 PAC:16972750 Cucumis sativus 367  
orange1.1g018253m A0A067GPN1 PAC:18107488 Citrus sinensis 359  
orange1.1g018443m A0A067GSD4 PAC:18107489 Citrus sinensis 356  
AT3G60880.1 Q9LZX6 PAC:19664668 Arabidopsis thaliana 364  
AT3G60880.2 Q9LZX6 PAC:19664667 Arabidopsis thaliana 365  
AT2G45440.1 Q9FVC8 PAC:19640355 Arabidopsis thaliana 365  
Thhalv10006047m V4L157 PAC:20190682 Eutrema salsugineum 365  
Thhalv10001513m V4LHD2 PAC:20189237 Eutrema salsugineum 364  
Thhalv10001510m V4L6A4 PAC:20189236 Eutrema salsugineum 365  
Ciclev10001707m V4T131 PAC:20785710 Citrus clementina 346  
Ciclev10001621m V4SGM3 PAC:20785709 Citrus clementina 359  
Lus10015861 PAC:23163276 Linum usitatissimum 362  
Lus10009302 PAC:23141878 Linum usitatissimum 362  
Potri.002G149500.1 B9GPI1 PAC:27022110 Populus trichocarpa 365  
Potri.014G071100.3 A0A2K1XRP0 PAC:27035191 Populus trichocarpa 318  
Potri.014G071100.2 PAC:27035190 Populus trichocarpa 362  
Potri.014G071100.1 B9IC12 PAC:27035189 Populus trichocarpa 363  
Gorai.004G160600.1 A0A0D2R5Q5 PAC:26776025 Gossypium raimondii 365  
Gorai.008G114500.1 A0A0D2SYZ8 PAC:26817515 Gossypium raimondii 365  
27640 I0Z625 PAC:27390578 Coccomyxa subellipsoidea C-169 354  
53072 I0Z2C8 PAC:27387304 Coccomyxa subellipsoidea C-169 310  
55708 C1MLG6 PAC:27343166 Micromonas pusilla CCMP1545 358  
77527 PAC:27399422 Micromonas sp RCC299 312  
78169 PAC:27399311 Micromonas sp RCC299 312  
31602 A4RX84 PAC:27416719 Ostreococcus lucimarinus 369  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1463470
            8349559
            9047371
            18186475
            22949190
            20025926