Protein Domain : IPR003314

Type:  Domain Name:  Mu-type HTH domain
Description:  Transposons are mobile genetic elements that move from one DNA site to another within their host's genome, often with profound biological consequences. TheMu genome is the largest and most efficient transposon known. The Mu transposase (MuA) is a multidomain protein, which is responsible fortranslocation of the Mu genome. Mu transposase can be divided into three structurally distinct domains, each with specific functions. The amino-terminal domain (30 kDa) is responsible for sequence-specific DNA binding and can further be subdivided into two separate subdomains, which bind an internalactivation sequence (IAS) and the ends of the phage genome, respectively. A highly homologous IAS binding domain is also present in the Mu repressorprotein (MuR), but its binding promotes lysogeny of the phage by repressing the expression of genes required for lytic growth and by directly blocking MuAaccess to the IAS. The IAS binding domains of the MuR and MuA proteins are DNA-binding, winged helix-turn-helix (wHTH) domains of about 75 residues (Mu-type HTH) [, ].The Mu-type HTH domain consists of a three-membered alpha-helical bundle buttressed by a three-stranded antiparallel beta-sheet with an overall B1-H1-T-H2-B2-W-B3-H3 topology (where B,H,T and W stand for beta-strand, alpha- helix, turn and wing, repectively. Helices H1 and H2 and theseven-residue turn connecting them comprise a helix-turn-helix (HTH) motif. While the general appearance of the Mu-type DNA-binding domain is similar tothat of other winged HTH proteins, the connectivity of the secondary structure elements is permuted. Hence this fold represents a novel class of winged HTHDNA-binding domain [, ]. Short Name:  Mu-type_HTH
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0 Child Features

1 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain

2 Cross Referencess

Identifier
PF02316
PS51702

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR003314

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR003314

1 Parent Features

DB identifier Type Name
IPR009061 Domain Putative DNA-binding domain

8 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.Scaffold_637.727 PAC:37876949 Coffea arabica 464  
HORVU4Hr1G000940.5 PAC:38571617 Hordeum vulgare 317  
Alyli.0010s0001.1.p PAC:39185609 Alyssum linifolium 384  
Thint.07G0588100.1.p PAC:40835205 Thinopyrum intermedium 365  
Pavir.3KG413800.3.p PAC:41609204 Panicum virgatum 459  
Pavir.3KG413800.4.p PAC:41609203 Panicum virgatum 459  
Pavir.3KG413800.2.p PAC:41609202 Panicum virgatum 469  
Pavag03G403900.1.p PAC:50320360 Paspalum vaginatum 574  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11135677
            7881904